TY  - JOUR
A1  - Grewers, Zoe
A1  - Krueger, Andreas
T1  - MicroRNA miR-181 - a rheostat for TCR signaling in thymic selection and peripheral T-Cell function
T2  - International journal of molecular sciences
N2  - The selection of T cells during intra-thymic d evelopment is crucial to obtain a functional and simultaneously not self-reactive peripheral T cell repertoire. However, selection is a complex process dependent on T cell receptor (TCR) thresholds that remain incompletely understood. In peripheral T cells, activation, clonal expansion, and contraction of the active T cell pool, as well as other processes depend on TCR signal strength. Members of the microRNA (miRNA) miR-181 family have been shown to be dynamically regulated during T cell development as well as dependent on the activation stage of T cells. Indeed, it has been shown that expression of miR-181a leads to the downregulation of multiple phosphatases, implicating miR-181a as ‘‘rheostat’’ of TCR signaling. Consistently, genetic models have revealed an essential role of miR-181a/b-1 for the generation of unconventional T cells as well as a function in tuning TCR sensitivity in peripheral T cells during aging. Here, we review these broad roles of miR-181 family members in T cell function via modulating TCR signal strength.
KW  - thymus
KW  - selection
KW  - unconventional T cell
KW  - T cell receptor
KW  - signaling
KW  - microRNA
KW  - miR-181
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/55919
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-559198
SN  - 1422-0067
N1  - © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
VL  - 21
IS  - 17, art. 6200
SP  - 1
EP  - 15
PB  - MDPI
CY  - Basel
ER  -