TY  - JOUR
A1  - Braun, Sebastian Benedict
A1  - Zaucke, Frank
A1  - Brenneis, Marco Uwe
A1  - Rapp, Anna Elise
A1  - Pollinger, Patrizia
A1  - Sohn, Rebecca
A1  - Jenei-Lanzl, Zsuzsa
A1  - Meurer, Andrea
T1  - The corpus adiposum infrapatellare (Hoffa’s fat pad) - the role of the infrapatellar fat pad in osteoarthritis pathogenesis
T2  - Biomedicines
N2  - In recent years, the infrapatellar fat pad (IFP) has gained increasing research interest. The contribution of the IFP to the development and progression of knee osteoarthritis (OA) through extensive interactions with the synovium, articular cartilage, and subchondral bone is being considered. As part of the initiation process of OA, IFP secretes abundant pro-inflammatory mediators among many other factors. Today, the IFP is (partially) resected in most total knee arthroplasties (TKA) allowing better visualization during surgical procedures. Currently, there is no clear guideline providing evidence in favor of or against IFP resection. With increasing numbers of TKAs, there is a focus on preventing adverse postoperative outcomes. Therefore, anatomic features, role in the development of knee OA, and consequences of resecting versus preserving the IFP during TKA are reviewed in the following article.
KW  - infrapatellar fat pad
KW  - knee osteoarthritis
KW  - total knee replacement
KW  - fat pad resection
KW  - inflammation
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/82376
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-823769
SN  - 2227-9059
N1  - This study was supported by a grant of the Deutsche Forschungsgemeinschaft (to Z.J.-L., JE 642/4-1, JE 642/4-2; project number 277277765) within the DFG Research Unit FOR2407 ExCarBon.
VL  - 10
IS  - 5, art. 1071
SP  - 1
EP  - 16
PB  - MDPI
CY  - Basel
ER  -