TY  - JOUR
A1  - Goldenberg, Ido
A1  - Erath, Julia W.
A1  - Russo, Andrea M.
A1  - Burch, Ashley E.
A1  - Aßmus, Birgit
A1  - Bonderman, Diana
A1  - McNitt, Scott
A1  - Kutyifa, Valentina
T1  - Sex differences in arrhythmic burden with the wearable cardioverter-defibrillator
T2  - Heart rhythm
N2  - Background: Data on the arrhythmic burden of women at risk for sudden cardiac death are limited, especially in patients using the wearable cardioverter-defibrillator (WCD).
Objective: We aimed to characterize WCD compliance, atrial and ventricular arrhythmic burden, and WCD outcomes by sex in patients enrolled in the Prospective Registry of Patients Using the Wearable Cardioverter Defibrillator (WEARIT-II U.S. Registry).
Methods: In the WEARIT-II Registry, we stratified 2000 patients by sex into women (n = 598) and men (n = 1402). WCD wear time, ventricular and atrial arrhythmic events during WCD use, and implantable cardioverter-defibrillator (ICD) implantation rates at the end of WCD use were evaluated.
Results: The mean WCD wear time was similar in women and men (94 days vs 90 days; P = .145), with longer daily use in women (21.4 h/d vs 20.7 h/d; P = .001). Burden of ventricular tachycardia or ventricular fibrillation was higher in women, with 30 events per 100 patient-years compared with 18 events per 100 patient-years in men (P = .017), with similar findings for treated and non-treated ventricular tachycardia/ventricular fibrillation. Recurrent atrial arrhythmias/sustained ventricular tachycardia was also more frequent in women than in men (167 events per 100 patient-years vs 73 events per 100 patient-years; P = .042). However, ICD implantation rate at the end of WCD use was similar in both women and men (41% vs 39%; P = .448).
Conclusion: In the WEARIT-II Registry, we have shown a higher burden of ventricular and atrial arrhythmic events in women than in men. ICD implantation rates at the end of WCD use were similar. Our findings warrant monitoring women at risk for sudden cardiac death who have a high burden of atrial and ventricular arrhythmias while using the WCD.
KW  - ICD
KW  - Outcomes
KW  - Sex
KW  - Ventricular arrhythmias
KW  - Wearable cardioverter-defibrillator
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/78169
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-781696
SN  - 1547-5271
VL  - 18.2021
IS  - 3
SP  - 404
EP  - 410
PB  - Elsevier
CY  - Amsterdam
ER  -