TY  - JOUR
A1  - López Jury, Luciana
A1  - García Rosales, Francisco
A1  - González Palomares, Eugenia
A1  - Wetekam, Johannes
A1  - Pasek, Michael
A1  - Hechavarria, Julio C.
T1  - A neuron model with unbalanced synaptic weights explains the asymmetric effects of anaesthesia on the auditory cortex
T2  - PLOS biology
N2  - Substantial progress in the field of neuroscience has been made from anaesthetized preparations. Ketamine is one of the most used drugs in electrophysiology studies, but how ketamine affects neuronal responses is poorly understood. Here, we used in vivo electrophysiology and computational modelling to study how the auditory cortex of bats responds to vocalisations under anaesthesia and in wakefulness. In wakefulness, acoustic context increases neuronal discrimination of natural sounds. Neuron models predicted that ketamine affects the contextual discrimination of sounds regardless of the type of context heard by the animals (echolocation or communication sounds). However, empirical evidence showed that the predicted effect of ketamine occurs only if the acoustic context consists of low-pitched sounds (e.g., communication calls in bats). Using the empirical data, we updated the naïve models to show that differential effects of ketamine on cortical responses can be mediated by unbalanced changes in the firing rate of feedforward inputs to cortex, and changes in the depression of thalamo-cortical synaptic receptors. Combined, our findings obtained in vivo and in silico reveal the effects and mechanisms by which ketamine affects cortical responses to vocalisations.
Y1  - 2023
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/83505
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-835054
SN  - 1545-7885
VL  - 21
IS  - 2, art. e3002013
PB  - PLoS
CY  - Lawrence, KS
ER  -