TY  - JOUR
A1  - Cano García, Cristina
A1  - Wenzel, Mike
A1  - Koll, Florestan
A1  - Zatik, Agnes
A1  - Köllermann, Jens
A1  - Graefen, Markus
A1  - Tilki, Derya
A1  - Karakiewicz, Pierre I.
A1  - Kluth, Luis A.
A1  - Chun, Felix
A1  - Mandel, Philipp
A1  - Höh, Benedikt
T1  - Differences in long-term continence rates between prostate cancer patients with extraprostatic vs. organ-confined disease undergoing robotic-assisted radical prostatectomy: an observational studys
T2  - Clinics
N2  - Objectives: Within the tertiary-case database, the authors tested for differences in long-term continence rates (≥ 12 months) between prostate cancer patients with extraprostatic vs. organ-confined disease who underwent Robotic-Assisted Radical Prostatectomy (RARP).
Method: In the institutional tertiary-care database the authors identified prostate cancer patients who underwent RARP between 01/2014 and 01/2021. The cohort was divided into two groups based on tumor extension in the final RARP specimen: patients with extraprostatic (pT3/4) vs. organ-confined (pT2) disease. Additionally, the authors conducted subgroup analyses within both the extraprostatic and organ-confined disease groups to compare continence rates before and after the implementation of the new surgical technique, which included Full Functional-Length Urethra preservation (FFLU) and Neurovascular Structure-Adjacent Frozen-Section Examination (NeuroSAFE). Multivariable logistic regression models addressing long-term continence were used.
Results: Overall, the authors identified 201 study patients of whom 75 (37 %) exhibited extraprostatic and 126 (63 %) organ-confined disease. There was no significant difference in long-term continence rates between patients with extraprostatic and organ-confined disease (77 vs. 83 %; p = 0.3). Following the implementation of FFLU+ NeuroSAFE, there was an overall improvement in continence from 67 % to 89 % (Δ = 22 %; p < 0.001). No difference in the magnitude of improved continence rates between extraprostatic vs. organ-confined disease was observed (Δ = 22 % vs. Δ = 20 %). In multivariable logistic regression models, no difference between extraprostatic vs. organ-confined disease in long-term continence was observed (Odds Ratio: 0.91; p = 0.85).
Conclusion: In this tertiary-based institutional study, patients with extraprostatic and organ-confined prostate cancer exhibited comparable long-term continence rates.
KW  - Long-term continence
KW  - Extraprostatic
KW  - Organ-confined
KW  - Robotic-assisted radical prostatectomy
KW  - FFLU
KW  - NeuroSAFE
Y1  - 2023
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/78842
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-788423
SN  - 1807-5932
VL  - 78
IS  - Art. 100284
PB  - Elsevier
CY  - Amsterdam
ER  -