TY  - JOUR
A1  - Figge, Marc Thilo
A1  - Meyer-Hermann, Michael
T1  - Geometrically repatterned immunological synapses uncover formation mechanisms
T2  - PLoS Computational Biology
N2  - The interaction of T cells and antigen-presenting cells is central to adaptive immunity and involves the formation of immunological synapses in many cases. The surface molecules of the cells form a characteristic spatial pattern whose formation mechanisms and function are largely unknown. We perform computer simulations of recent experiments on geometrically repatterned immunological synapses and explain the emerging structure as well as the formation dynamics. Only the combination of in vitro experiments and computer simulations has the potential to pinpoint the kind of interactions involved. The presented simulations make clear predictions for the structure of the immunological synapse and elucidate the role of a self-organizing attraction between complexes of T cell receptor and peptide–MHC molecule, versus a centrally directed motion of these complexes.
Y1  - 2006
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/2109
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-33205
SN  - 1553-7358
N1  - © 2006 Figge and Meyer-Hermann. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 2
IS  - (11): e171
SP  - 1377
EP  - 1384
PB  - PLoS
CY  - Lawrence, Kan.
ER  -