TY  - JOUR
A1  - Beecken, Wolf-Dietrich
A1  - Kramer, Wolfgang
A1  - Jonas, Dietger
T1  - New molecular mediators in tumor angiogenesis
T2  - Journal of cellular and molecular medicine
N2  - Angiogenesis is essential for tumor growth and progression. It has been demonstrated that tumor growth beyond a size 1 to 2 mm3 requires the induction of new vessels. Angiogenesis is regulated by several endogenous stimulators and inhibitors of endothelial cell migration, proliferation and tube formation. Under physiological conditions these mediators of endothelial cell growth are in balance and vessel growth is limited. In fact, within the angiogenic balance endothelial cell turnover is sufficient to maintain a functional vascular wall but does not allow vessel growth. Tumor growth an progression has successfully been correlated to the serum concentration of angiogenic mediators. Furthermore, the vascular density of tumor tissues could be correlated to the clinical course of the disease in several tumor entities. Within the last years several new mediators of endothelial cell growth have been isolated e.g. angiopoietin 1, angiopoietin 2, midkine, pleiotropin, leptin and maspin. In this review we discuss the mechanisms leading to tumor angiogenesis and describe some of the newer mediators of endothelial cell stimulation and inhibition.
KW  - tumor angiogenesis
KW  - angiopoietins
KW  - leptin
KW  - midkine
KW  - pleiotropin
KW  - maspin
Y1  - 2001
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/27919
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-279198
SN  - 1582-4934
SN  - 1582-1838
N1  - This is an Open Access article under the terms of the Creative Commons Attribution Non Commercial License http://creativecommons.org/licenses/by-nc/3.0/ which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
VL  - 4
IS  - 4
SP  - 262
EP  - 269
PB  - Wiley-Blackwell
CY  - Hoboken, NJ
ER  -