TY  - JOUR
A1  - Scharnagl, Hubert
A1  - Kleber, Marcus E.
A1  - Genser, Bernd
A1  - Kickmaier, Sandra
A1  - Renner, Wilfried
A1  - Weihrauch, Gisela
A1  - Grammer, Tanja B.
A1  - Rossmann, Christine
A1  - Winkelmann, Bernhard R.
A1  - Böhm, Bernhard O.
A1  - Sattler, Wolfgang
A1  - März, Winfried
A1  - Malle, Ernst
T1  - Association of myeloperoxidase with total and cardiovascular mortality in individuals undergoing coronary angiography : the LURIC study
T2  - International journal of cardiology
N2  - Background: The phagocytic enzyme myeloperoxidase (MPO) acts as a front-line defender against microorganisms. However, increased MPO levels have been found to be associated with complex and calcified atherosclerotic lesions and incident cardiovascular disease. Therefore, this study aimed to investigate a predictive role of MPO, a biomarker of inflammation and oxidative stress, for total and cardiovascular mortality in patients referred to coronary angiography.
Methods and results: MPO plasma concentrations along with eight MPO polymorphisms were determined in 3036 participants of the Ludwigshafen Risk and Cardiovascular Health study (median follow-up 7.75 years). MPO concentrations were positively associated with age, diabetes, smoking, markers of systemic inflammation (interleukin-6, fibrinogen, C-reactive protein, serum amyloid A) and vascular damage (vascular cellular adhesion molecule-1 and intercellular adhesion molecule-1) but negatively associated with HDL-cholesterol and apolipoprotein A-I. After adjustment for cardiovascular risk factors MPO concentrations in the highest versus the lowest quartile were associated with a 1.34-fold risk (95% CI: 1.09–1.67) for total mortality. In the adjusted model the hazard ratio for cardiovascular mortality in the highest MPO quartile was 1.42 (95% CI: 1.07–1.88). Five MPO polymorphisms were positively associated with MPO concentrations but not with mortality. Using Mendelian randomization, we did not obtain evidence for a causal association of MPO with either total or cardiovascular mortality.
Conclusions: MPO concentrations but not genetic variants at the MPO locus are independently associated with risk for total and cardiovascular mortality in coronary artery disease patients.
KW  - Myeloperoxidase
KW  - Inflammation
KW  - High-density lipoprotein
KW  - Cardiovascular mortality
KW  - Risk factor
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/36476
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-364760
SN  - 0167-5273
N1  - This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
VL  - 174
IS  - 1
SP  - 96
EP  - 105
PB  - Elsevier Science
CY  - Amsterdam [u.a.]
ER  -