TY  - JOUR
A1  - Steinmetz, Martin
A1  - Schmitter, Charlotte
A1  - Radecke, Tobias
A1  - Stundl, Anja
A1  - Nickenig, Georg
A1  - Schaefer, Christian
A1  - Schahab, Nadjib
A1  - Vasa-Nicotera, Mariuca
A1  - Sinning, Jan-Malte
T1  - Brief report – Telomere length is a poor biomarker to predict 1-year mortality or cardiovascular comorbidity in patients with transcatheter aortic valve replacement
T2  - PLoS one
N2  - Background: Transcatheter aortic valve replacement (TAVR) is a therapeutic option for patients with aortic valve stenosis at increased surgical risk. Telomeres are an established marker for cellular senescence and have served to evaluate cardiovascular diseases including severe aortic valve stenosis. In our study, we hypothesized that telomere length may be a predictor for outcome and associated with comorbidities in patients with TAVR.
Methods and results: We analyzed leucocyte telomere length from 155 patients who underwent TAVR and correlated the results with 1-year mortality and severe comorbidities. The cohort was subdivided into 3 groups according to telomere length. Although a trend for a positive correlation of telomere length with a lower EuroSCORE could be found, telomere length was not associated with survival, aortic valve opening area or cardiovascular comorbidities (peripheral, coronary or cerebrovascular disease). Interestingly, long telomeres were significantly correlated to a reduced left ventricular ejection fraction (LVEF).
Conclusion: In elderly patients with severe aortic valve stenosis, leucocyte telomere length did not predict post-procedural survival. The correlation between long telomere length and reduced LVEF in these patients deserves further attention.
KW  - Telomere length
KW  - Telomeres
KW  - Aortic valve
KW  - Coronary heart disease
KW  - Stenosis
KW  - White blood cells
KW  - Ejection fraction
KW  - Aortic valve replacement
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/48525
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-485256
SN  - 1932-6203
N1  - Copyright: © 2019 Steinmetz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 14
IS  - (3): e0213250
SP  - 1
EP  - 6
PB  - PLoS
CY  - Lawrence, Kan.
ER  -