TY  - JOUR
A1  - Ramich, Tatjana
A1  - Asendorf, Anne
A1  - Nickles, Katrin
A1  - Oremek, Gerhard
A1  - Schubert, Ralf
A1  - Nibali, Luigi
A1  - Wohlfeil, Martin
A1  - Eickholz, Peter
T1  - Inflammatory serum markers up to 5 years after comprehensive periodontal therapy of aggressive and chronic periodontitis
T2  - Clinical oral investigations
N2  - Aim: The aim of the study is to assess the long-term effect of active periodontal therapy on serum inflammatory parameters in patients with aggressive (AgP) and chronic (ChP) periodontitis in a non-randomised clinical study.
Methods: Twenty-five ChP and 17 AgP were examined clinically prior to (baseline), 12 weeks and 60 months after subgingival debridement of all pockets within 2 days. Systemic antibiotics were prescribed if Aggregatibacter actinomycetemcomitans was detected (10 AgP, 8 ChP), flap surgery was rendered if required. Neutrophil elastase (NE), C-reactive protein (CRP), lipopolysaccharide binding protein, interleukin 6, 8, and leukocyte counts were assessed at baseline, 12 weeks and 60 months.
Results: Clinical parameters improved significantly in both groups from 12 weeks to 60 months. Eleven AgP and 18 ChP patients received surgical treatment after the 12 weeks examination. Only 3 patients in each group attended ≥ 2 supportive maintenance visits per year. NE and CRP were significantly higher in AgP than ChP at baseline and 60 months (p < 0.01). For leukocyte counts in ChP, significant changes were observed (baseline: 6.11 ± 1.44 nl−1; 12 weeks: 5.34 ± 1.40 nl−1; 60 months: 7.73 ± 2.89 nl−1; p < 0.05). Multiple regression analysis identified African origin, surgical treatment and female sex to correlate with better clinical improvement.
Conclusion: Despite comprehensive periodontal treatment, AgP patients exhibit higher NE and CRP levels than ChP patients up to 5 years after therapy.
Clinical relevance: Systemic inflammatory burden in AgP patients is higher than in ChP patients even 5 years after periodontal treatment.
KW  - Leukocyte elastase
KW  - C-reactive protein
KW  - Lipopolysaccharide-binding protein
KW  - Interleukin-6
KW  - Aggressive periodontitis
KW  - Chronic periodontiti
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50244
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-502440
SN  - 1436-3771
SN  - 1432-6981
N1  - Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
VL  - 22
IS  - 9
SP  - 3079
EP  - 3089
PB  - Springer
CY  - Berlin ; Heidelberg
ER  -