The S-adenosylmethionine dependent O-methyltransferase PaMTH1: a longevity assurance factor protecting Podospora anserina against oxidative stress
PaMTH1 is an O-methyltransferase catalysing the methylation of vicinal hydroxyl groups of polyphenols. The protein accumulates during ageing of Podospora anserina in both the cytosol and in the mitochondrial matrix. The construction and characterisation of a PaMth1 deletion strain provided additional evidence about the function of the protein in the protection against metal induced oxidative stress. Deletion of PaMth1 was found to lead to a decreased resistance against exogenous oxidative stress and to a shortened lifespan suggesting a role of PaMTH1 as a longevity assurance factor in a new molecular pathway involved in lifespan control. Key words: Podospora anserina, knock-out, reactive oxygen species, flavonoids, ageing, O-methyltransferase
| Author: | Birgit Kunstmann, Heinz D. Osiewacz |
|---|---|
| URN: | urn:nbn:de:hebis:30-83904 |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 26.10.2010 |
| Year of first Publication: | 2009 |
| Publishing Institution: | Univ.-Bibliothek Frankfurt am Main |
| Tag: | O-methyltransferase; Podospora anserina ; ageing ; flavonoids ; knock-out ; reactive oxygen species |
| Source: | AGING, Vol 1, No 3, pp 328-334 ; http://www.impactaging.com/papers/v1/n3/full/100029.html |
| HeBIS PPN: | 229860907 |
| Institutes: | Biowissenschaften |
| Dewey Decimal Classification: | 570 Biowissenschaften; Biologie |
| Sammlungen: | Universitätspublikationen |
| Note: | Copyright: © 2009 Kunstmann and Osiewacz. This is an open‐access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Licence (German): |  Veröffentlichungsvertrag für Publikationen ohne Print on Demand |
