Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity

Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rate
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates. Here we identify for the first time a multifunctional surface lipoprotein of B. recurrentis, termed HcpA, and demonstrate that it binds human complement regulators, Factor H, CFHR-1, and simultaneously, the host protease plasminogen. Cell surface bound factor H was found to retain its activity and to confer resistance to complement attack. Moreover, ectopic expression of HcpA in a B. burgdorferi B313 strain, deficient in Factor H binding proteins, protected the transformed spirochetes from complement-mediated killing. Furthermore, HcpA-bound plasminogen/plasmin endows B. recurrentis with the potential to resist opsonization and to degrade extracellular matrix components. Together, the present study underscores the high virulence potential of B. recurrentis. The elucidation of the molecular basis underlying the versatile strategies of B. recurrentis to escape innate immunity and to persist in human tissues, including the brain, may help to understand the pathological processes underlying louse-borne relapsing fever.
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Metadaten
Author:Sonja Grosskinsky, Melanie Schott, Christiane Brenner, Sally J. Cutler, Peter Kraiczy, Peter F. Zipfel, Markus M. Simon, Reinhard Wallich
URN:urn:nbn:de:hebis:30-114400
DOI:http://dx.doi.org/10.1371/journal.pone.0004858
ISSN:1932-6203
Parent Title (English):PLoS One
Document Type:Article
Language:English
Date of Publication (online):2009/03/24
Date of first Publication:2009/03/24
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2011/09/06
Volume:4
Issue:(3): e4858
Note:
Copyright: © 2009 Grosskinsky et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source:PLoS ONE 4(3): e4858. doi: 10.1371/journal.pone.0004858
HeBIS PPN:276030567
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Sondersammelgebiets-Volltexte
Licence (German):License LogoCreative Commons - Namensnennung 3.0

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