Long-term effects of treatment and response in patients with chronic hepatitis C on quality of life : an international, multicenter, randomized, controlled study

Background: Hepatitis C decreases health related quality of life (HRQL) which is further diminished by antiviral therapy. HRQL improves after successful treatment. This trial explores the course of and factors associated
Background: Hepatitis C decreases health related quality of life (HRQL) which is further diminished by antiviral therapy. HRQL improves after successful treatment. This trial explores the course of and factors associated with HRQL in patients given individualized or standard treatment based on early treatment response (Ditto-study).

Methods: The Short Form (SF)-36 Health Survey was administered at baseline (n = 192) and 24 weeks after the end of therapy (n = 128).

Results: At baseline HRQL was influenced by age, participating center, severity of liver disease and income. Exploring the course of HRQL (scores at follow up minus baseline), only the dimension general health increased. In this dimension patients with a relapse or sustained response differed from non-responders. Men and women differed in the dimension bodily pain. Treatment schedule did not influence the course of HRQL.

Conclusions: Main determinants of HRQL were severity of liver disease, age, gender, participating center and response to treatment. Our results do not exclude a more profound negative impact of individualized treatment compared to standard, possibly caused by higher doses and extended treatment duration in the individualized group. Antiviral therapy might have a more intense and more prolonged negative impact on females.
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Metadaten
Author:Geert Bezemer, Arthur R. van Gool, Elke Verheij-Hart, Bettina E. Hansen, Yoav Lurie, Juan I. Esteban, Martin Lagging, Francesco Negro, Stefan Zeuzem, Carlo Ferrari, Jean-Michel Pawlotsky, Avidan U. Neumann, Solko Walle Schalm, Robert Jacobus de Knegt
URN:urn:nbn:de:hebis:30:3-240657
DOI:http://dx.doi.org/doi:10.1186/1471-230X-12-11
ISSN:1471-230X
Parent Title (English):BMC gastroenterology
Publisher:BioMed Central
Place of publication:London
Document Type:Article
Language:English
Date of Publication (online):2012/03/12
Date of first Publication:2012/01/31
Publishing Institution:Univ.-Bibliothek Frankfurt am Main
Contributing Corporation:DITTO-HCV Study Group
Release Date:2012/03/12
Tag:health related quality of life; hepatitis C; peginterferon
Volume:12
Issue:11
Pagenumber:7
HeBIS PPN:31089090X
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 3.0

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