Wound healing in mice with high-fat diet- or ob gene-induced diabetes-obesity syndromes : a comparative study

In the past, the genetically diabetic-obese diabetes/diabetes (db/db) and obese/obese (ob/ob) mouse strains were used to investigate mechanisms of diabetes-impaired wound healing. Here we determined patterns of skin repa
In the past, the genetically diabetic-obese diabetes/diabetes (db/db) and obese/obese (ob/ob) mouse strains were used to investigate mechanisms of diabetes-impaired wound healing. Here we determined patterns of skin repair in genetically normal C57Bl/6J mice that were fed using a high fat diet (HFD) to induce a diabetes-obesity syndrome. Wound closure was markedly delayed in HFD-fed mice compared to mice which had received a standard chow diet (CD). Impaired wound tissue of HFD mice showed a marked prolongation of wound inflammation. Expression of vascular endothelial growth factor (VEGF) was delayed and associated with the disturbed formation of wound margin epithelia and an impaired angiogenesis in the reduced granulation tissue. Normal wound contraction was retarded and disordered. Wound disorders in obese C57Bl/6J mice were paralleled by a prominent degradation of the inhibitor of NFκB (IκB-α) in the absence of an Akt activation. By contrast to impaired wound conditions in ob/ob mice, late wounds of HFD mice did not develop a chronic inflammatory state and were epithelialized after 11 days of repair. Thus, only genetically obese and diabetic ob/ob mice finally developed chronic wounds and therefore represent a better suited experimental model to investigate diabetes-induced wound healing disorders.
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Author:Oliver Seitz, Christoph Schürmann, Nadine Hermes, Elke Müller, Josef Martin Pfeilschifter, Stefan Frank, Itamar Goren
URN:urn:nbn:de:hebis:30:3-241752
DOI:http://dx.doi.org/doi:10.1155/2010/476969
ISSN:1687-5303
ISSN:1687-5214
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=21318183
Parent Title (English):Experimental diabetes research
Publisher:Hindawi
Place of publication:New York, NY [u. a.]
Contributor(s):Nils Welsh
Document Type:Article
Language:English
Year of Completion:2012
Year of first Publication:2010
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2012/05/30
Volume:2010
Issue:Art. 476969
Pagenumber:15
First Page:1
Last Page:15
Note:
Copyright © 2010 Oliver Seitz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
HeBIS PPN:30300343X
Institutes:Pharmazie
Medizin
Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 3.0

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