Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum

The synthesis of the recently characterized depsipeptide szentiamide (1), which is produced by the entomopathogenic bacterium Xenorhabdus szentirmaii, is described. Whereas no biological activity was previously identifie
The synthesis of the recently characterized depsipeptide szentiamide (1), which is produced by the entomopathogenic bacterium Xenorhabdus szentirmaii, is described. Whereas no biological activity was previously identified for 1, the material derived from the efficient synthesis enabled additional bioactivity tests leading to the identification of a notable activity against insect cells and Plasmodium falciparum, the causative agent of malaria.
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Metadaten
Author:Friederike I. Nollmann, Andrea Dowling, Marcel Kaiser, Klaus Deckmann, Sabine Grösch, Richard ffrench-Constant, Helge Björn Bode
URN:urn:nbn:de:hebis:30:3-252060
DOI:http://dx.doi.org/10.3762/bjoc.8.60
ISSN:1860-5397
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=22563351
Parent Title (English):Beilstein journal of organic chemistry
Publisher:Hindawi
Place of publication:New York, NY
Document Type:Article
Language:English
Date of Publication (online):2012/04/11
Date of first Publication:2012/04/11
Publishing Institution:Univ.-Bibliothek Frankfurt am Main
Release Date:2012/06/27
Tag:Xenorhabdus; cyclic depsipeptide; esterification; natural product; szentiamide
Volume:7
Institutes:Biowissenschaften
Medizin
Dewey Decimal Classification:540 Chemie und zugeordnete Wissenschaften
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 3.0

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