Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum
The synthesis of the recently characterized depsipeptide szentiamide (1), which is produced by the entomopathogenic bacterium Xenorhabdus szentirmaii, is described. Whereas no biological activity was previously identified for 1, the material derived from the efficient synthesis enabled additional bioactivity tests leading to the identification of a notable activity against insect cells and Plasmodium falciparum, the causative agent of malaria.
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| Author: | Friederike I. Nollmann, Andrea Dowling, Marcel Kaiser, Klaus Deckmann, Sabine Grösch, Richard ffrench-Constant, Helge Björn Bode |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-252060 |
| DOI: | http://dx.doi.org/10.3762/bjoc.8.60 |
| ISSN: | 1860-5397 |
| Pubmed Id: | http://www.ncbi.nlm.nih.gov/pubmed?term=22563351 |
| Parent Title (English): | Beilstein journal of organic chemistry |
| Publisher: | Hindawi |
| Place of publication: | New York, NY |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 11.04.2012 |
| Date of first Publication: | 11.04.2012 |
| Publishing Institution: | Univ.-Bibliothek Frankfurt am Main |
| Tag: | Xenorhabdus; cyclic depsipeptide; esterification; natural product; szentiamide |
| Volume: | 7 |
| Institutes: | Biowissenschaften |
| Medizin | |
| Dewey Decimal Classification: | 540 Chemie und zugeordnete Wissenschaften |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung 3.0 |
