Components of cell-matrix linkage as potential new markers for prostate cancer
- Prostate cancer is one of the most common tumor diseases worldwide. Often being non-aggressive, prostate tumors in these cases do not need immediate treatment. However, about 20% of diagnosed prostate cancers tend to metastasize and require treatment. Existing diagnostic methods may fail to accurately recognize the transition of a dormant, non-aggressive tumor into highly malignant prostate cancer. Therefore, new diagnostic tools are needed to improve diagnosis and therapy of prostate carcinoma. This review evaluates existing methods to diagnose prostate carcinoma, such as the biochemical marker prostate-specific antigen (PSA), but also discusses the possibility to use the altered expression of integrins and laminin-332 in prostate carcinomas as diagnostic tools and therapeutic targets of prostate cancer.
| Author: | Alexey Navdaev, Johannes A. EbleORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-252151 |
| DOI: | https://doi.org/10.3390/cancers3010883 |
| ISSN: | 2072-6694 |
| Parent Title (English): | Cancers |
| Publisher: | Molecular Diversity Preservation International (MDPI) |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2012/02/25 |
| Date of first Publication: | 2012/02/25 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2012/06/22 |
| Tag: | diagnosis; integrins; laminins; prostate cancer; proteases |
| Volume: | 3 |
| Issue: | 1 |
| Page Number: | 14 |
| First Page: | 883 |
| Last Page: | 896 |
| HeBIS-PPN: | 357459431 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung 3.0 |
