Synthesis of 1,4-Disubstituted Mono and Bis-triazolocarbo-acyclonucleoside Analogues of 9-(4-Hydroxybutyl)guanine by Cu(I)-Catalyzed Click Azide-Alkyne Cycloaddition
A series of novel mono-1,2,3-triazole and bis-1,2,3-triazole acyclonucleoside analogues of 9-(4-hydroxybutyl)guanine was prepared via copper(I)-catalyzed 1,3-dipolar cycloaddition of N-9 propargylpurine, N-1-propargylpyrimidines/as-triazine with the azido-pseudo-sugar 4-azidobutylacetate under solvent-free microwave conditions, followed by treatment with K2CO3/MeOH, or NH3/MeOH. All compounds studied in this work were screened for their antiviral activities [against human rhinovirus (HRV) and hepatitis C virus (HCV)] and antibacterial activities against a series of Gram positive and negative bacteria.
| Author: | Jamal Krim, Mohamed Taourirte, Joachim W. Engels |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-259394 |
| DOI: | http://dx.doi.org/10.3390/molecules17010179 |
| ISSN: | 1420-3049 |
| Pubmed Id: | http://www.ncbi.nlm.nih.gov/pubmed?term=22202806 |
| Parent Title (English): | Molecules |
| Publisher: | Molecular Diversity Preservation International (MDPI) |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 27.12.2011 |
| Date of first Publication: | 27.12.2011 |
| Publishing Institution: | Univ.-Bibliothek Frankfurt am Main |
| Tag: | 1,2,3 triazole; 1,2,3-bis-triazoles; 1,3-dipolar cycloaddition; antibacterial activities; click azide-alkyne; microwave-assisted synthesis |
| Volume: | 17 |
| Issue: | 1 |
| Pagenumber: | 12 |
| First Page: | 179 |
| Last Page: | 190 |
| Institutes: | Biochemie und Chemie |
| Dewey Decimal Classification: | 540 Chemie und zugeordnete Wissenschaften |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung 3.0 |
