Venomous secretions from marine snails of the Terebridae family target acetylcholine receptors

Venoms from cone snails (Conidae) have been extensively studied during the last decades, but those from other members of the suborder Toxoglossa, such as of Terebridae and Turridae superfamilies attracted less interest s
Venoms from cone snails (Conidae) have been extensively studied during the last decades, but those from other members of the suborder Toxoglossa, such as of Terebridae and Turridae superfamilies attracted less interest so far. Here, we report the effects of venom and gland extracts from three species of the superfamily Terebridae. By 2-electrode voltage-clamp technique the gland extracts were tested on Xenopus oocytes expressing nicotinic acetylcholine receptors (nAChRs) of rat neuronal (α3β2, α3β4, α4β2, α4β4, α7) and muscle subtypes (α1β1γδ), and expressing potassium (Kv1.2 and Kv1.3) and sodium channels (Nav1.2, 1.3, 1.4, 1.6). The extracts were shown to exhibit remarkably high inhibitory activities on almost all nAChRs tested, in particular on the α7 subtype suggesting the presence of peptides of the A-superfamily from the venom of Conus species. In contrast, no effects on the potassium and sodium channels tested were observed. The venoms of terebrid snails may offer an additional source of novel biologically active peptides.
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Author:Yvonne Kendel, Christian Melaun, Alexander Kurz, Annette Nicke, Steve Peigneur, Jan Tytgat, Cora Wunder, Dietrich Mebs, Silke Kauferstein
URN:urn:nbn:de:hebis:30:3-263468
DOI:http://dx.doi.org/10.3390/toxins5051043
ISSN:2072-6651
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=23698359
Parent Title (English):Toxins
Publisher:Molecular Diversity Preservation Internat. (MDPI)
Place of publication:Basel
Document Type:Article
Language:English
Year of Completion:2013
Date of first Publication:2013/05/21
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2013/05/23
Tag:acetylcholine receptors; gland extracts; potassium channels; sodium channels; terebridae venom
Volume:5
Issue:5
Pagenumber:8
First Page:1043
Last Page:1050
Note:
© 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
HeBIS PPN:339679476
Institutes:Medizin
Senckenbergische Naturforschende Gesellschaft
Biodiversität und Klima Forschungszentrum (BiK-F)
Dewey Decimal Classification:590 Tiere (Zoologie)
Sammlungen:Universitätspublikationen
Sondersammelgebiets-Volltexte
Licence (German):License LogoCreative Commons - Namensnennung 3.0

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