Hyperoxia reversibly alters oxygen consumption and metabolism

AIM: Ventilation with pure oxygen (hyperoxic ventilation: HV) is thought to decrease whole body oxygen consumption (VO(2)). However, the validity and impact of this phenomenon remain ambiguous; until now, under hyperoxic
AIM: Ventilation with pure oxygen (hyperoxic ventilation: HV) is thought to decrease whole body oxygen consumption (VO(2)). However, the validity and impact of this phenomenon remain ambiguous; until now, under hyperoxic conditions, VO(2) has only been determined by the reverse Fick principle, a method with inherent methodological problems. The goal of this study was to determine changes of VO(2), carbon dioxide production (VCO(2)), and the respiratory quotient (RQ) during normoxic and hyperoxic ventilation, using a metabolic monitor.

METHODS: After providing signed informed consent and institutional acceptance, 14 healthy volunteers were asked to sequentially breathe room air, pure oxygen, and room air again. VO(2), VCO(2), RQ, and energy expenditure (EE) were determined by indirect calorimetry using a modified metabolic monitor during HV.

RESULTS: HV reduced VO(2) from 3.4 (3.0/4.0) mL/kg/min to 2.8 (2.5/3.6) mL/kg/min (P < 0.05), whereas VCO(2) remained constant (3.0 [2.6/3.6] mL/kg/min versus 3.0 [2.6/3.5] mL/kg/min, n.s.). After onset of HV, RQ increased from 0.9 (0.8/0.9) to 1.1 (1.0/1.1). Most changes during HV were immediately reversed during subsequent normoxic ventilation.

CONCLUSION: HV not only reduces VO(2), but also increases the respiratory quotient. This might be interpreted as an indicator of the substantial metabolic changes induced by HV. However, the impact of this phenomenon requires further study.
show moreshow less

Download full text files

Export metadata

  • Export Bibtex
  • Export RIS

Additional Services

    Share in Twitter Search Google Scholar
Metadaten
Author:Patrick Lauscher, Sabine Lauscher, Harry Kertscho, Oliver Habler, Jens Meier
URN:urn:nbn:de:hebis:30:3-267725
DOI:http://dx.doi.org/10.1100/2012/410321
ISSN:1537-744X
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=22623894
Parent Title (English):The Scientific World Journal
Place of publication:Boynton Beach, Fla.
Document Type:Article
Language:English
Date of Publication (online):2012/05/01
Date of first Publication:2012/05/01
Publishing Institution:Univ.-Bibliothek Frankfurt am Main
Release Date:2012/10/12
Volume:2012
Issue:Article ID 410321
Pagenumber:6
First Page:1
Last Page:6
Note:
Copyright © 2012 Patrick Lauscher et al. This is an open access article distributed under the   Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 3.0

$Rev: 11761 $