Nanolesions induced by heavy ions in human tissues: experimental and theoretical studies

The biological effects of energetic heavy ions are attracting increasing interest for their applications in cancer therapy and protection against space radiation. The cascade of events leading to cell death or late effec
The biological effects of energetic heavy ions are attracting increasing interest for their applications in cancer therapy and protection against space radiation. The cascade of events leading to cell death or late effects starts from stochastic energy deposition on the nanometer scale and the corresponding lesions in biological molecules, primarily DNA. We have developed experimental techniques to visualize DNA nanolesions induced by heavy ions. Nanolesions appear in cells as “streaks” which can be visualized by using different DNA repair markers. We have studied the kinetics of repair of these “streaks” also with respect to the chromatin conformation. Initial steps in the modeling of the energy deposition patterns at the micrometer and nanometer scale were made with MCHIT and TRAX models, respectively.
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Author:Marcus Bleicher, Lucas Burigo, Marco Durante, Maren Herrlitz, Michael Krämer, Igor Mishustin, Iris Müller, Francesco Natale, Igor Pshenichnov, Stefan Schramm, Gisela Taucher-Scholz, Cathrin Wälzlein
URN:urn:nbn:de:hebis:30:3-277769
DOI:http://dx.doi.org/10.3762/bjnano.3.64
ISSN:2190-4286
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=23019551
Parent Title (English):Beilstein Journal of Nanotechnology
Publisher:Beilstein-Institut zur Förderung der Chemischen Wissenschaften
Place of publication:Frankfurt, M.
Document Type:Article
Language:English
Date of Publication (online):2012/07/25
Date of first Publication:2012/07/25
Publishing Institution:Univ.-Bibliothek Frankfurt am Main
Release Date:2012/12/13
Tag:DNA repair; Monte Carlo simulations; heavy ions; microdosimetry; nanolesions; radiation-induced nanostructures
Volume:3
Pagenumber:8
First Page:556
Last Page:563
Note:
This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Institutes:Physik
Frankfurt Institute for Advanced Studies (FIAS)
Center for Scientific Computing (CSC)
Dewey Decimal Classification:530 Physik
620 Ingenieurwissenschaften und zugeordnete Tätigkeiten
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 2.0

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