MicroRNAs in age-related diseases
- Aging is a complex process that is linked to an increased incidence of major diseases such as cardiovascular and neurodegenerative disease, but also cancer and immune disorders. MicroRNAs (miRNAs) are small non-coding RNAs, which post-transcriptionally control gene expression by inhibiting translation or inducing degradation of targeted mRNAs. MiRNAs target up to hundreds of mRNAs, thereby modulating gene expression patterns. Many miRNAs appear to be dysregulated during cellular senescence, aging and disease. However, only few miRNAs have been so far linked to age-related changes in cellular and organ functions. The present article will discuss these findings, specifically focusing on the cardiovascular and neurological systems.
| Author: | Stefanie DimmelerORCiDGND, Pierluigi Nicotera |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-287890 |
| DOI: | https://doi.org/10.1002/emmm.201201986 |
| ISSN: | 1715-4684 |
| ISSN: | 1757-4676 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/23339066 |
| Parent Title (English): | EMBO molecular medicine |
| Publisher: | Wiley-VCH |
| Place of publication: | Weinheim |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2013/01/22 |
| Date of first Publication: | 2013/01/22 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2013/02/07 |
| Tag: | cardiac; microRNA; neurodegeneration; senescence; vascular |
| Volume: | 5 |
| Issue: | 2 |
| Page Number: | 11 |
| First Page: | 180 |
| Last Page: | 190 |
| Note: | Copyright © 2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO. This is an Open Access article under the terms of the Creative Commons Attribution Non Commercial License http://creativecommons.org/licenses/by-nc/3.0/ which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| HeBIS-PPN: | 33118821X |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell 3.0 |
