Identification and isolation of insecticidal oxazoles from Pseudomonas spp.

  • Two new and five known oxazoles were identified from two different Pseudomonas strains in addition to the known pyrones pseudopyronine A and B. Labeling experiments confirmed their structures and gave initial evidence for a novel biosynthesis pathway of these natural oxazoles. In order to confirm their structure, they were synthesized, which also allowed tests of their bioactivity. Additionally, the bioactivities of the synthesis intermediates were also investigated revealing interesting biological activities for several compounds despite their overall simple structures.

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Author:Florian Grundmann, Veronika Dill, Andrea Dowling, Aunchalee Thanwisai, Edna BodeORCiDGND, Narisara Chantratita, Richard ffrench-Constant, Helge Björn BodeORCiDGND
URN:urn:nbn:de:hebis:30:3-288799
DOI:https://doi.org/10.3762/bjoc.8.85
ISSN:1860-5397
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/23015823
Parent Title (English):Beilstein journal of organic chemistry
Publisher:Frankfurt, Main
Place of publication:Beilstein-Institut zur Förderung der Chemischen Wissenschaften
Document Type:Article
Language:English
Date of Publication (online):2012/05/18
Date of first Publication:2012/05/18
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2013/02/14
Tag:Pseudomonas; insecticidal activity; labradorin; oxazole; secondary metabolite
Volume:8
Page Number:4
First Page:749
Last Page:752
Note:
Copyright © 2012, Grundmann et al; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)
HeBIS-PPN:331513404
Institutes:Biowissenschaften / Biowissenschaften
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Sammlungen:Universitätspublikationen
Sammlung Biologie / Sondersammelgebiets-Volltexte
Licence (German):License LogoCreative Commons - Namensnennung 2.0