The extension of the Periodic System into hitherto unexplored domains - anti- matter and hypermatter - is discussed. Starting from an analysis of hyperon and single hypernuclear properties we investigate the structure of multi-hyperon objects (MEMOs) using an extended relativistic meson field theory. These are contrasted with multi-strange quark states (strangelets). Their production mechanism is stud- ied for relativistic collisions of heavy ions from present day experiments at AGS and SPS to future opportunities at RHIC and LHC. It is pointed out that abso- lutely stable hypermatter is unlikely to be produced in heavy ion collisions. New attention should be focused on short lived metastable hyperclusters ( / 10 10s) and on intensity interferometry of multi-strange-baryon correlations.