Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited

  • The cellular and molecular mechanisms of tumor angiogenesis and its prospects for anti-angiogenic cancer therapy are major issues in almost all current concepts of both cancer biology and targeted cancer therapy. Currently, (1) sprouting angiogenesis, (2) vascular co-option, (3) vascular intussusception, (4) vasculogenic mimicry, (5) bone marrow-derived vasculogenesis, (6) cancer stem-like cell-derived vasculogenesis and (7) myeloid cell-driven angiogenesis are all considered to contribute to tumor angiogenesis. Many of these processes have been described in developmental angiogenesis; however, the relative contribution and relevance of these in human brain cancer remain unclear. Preclinical tumor models support a role for sprouting angiogenesis, vascular co-option and myeloid cell-derived angiogenesis in glioma vascularization, whereas a role for the other four mechanisms remains controversial and rather enigmatic. The anti-angiogenesis drug Avastin (Bevacizumab), which targets VEGF, has become one of the most popular cancer drugs in the world. Anti-angiogenic therapy may lead to vascular normalization and as such facilitate conventional cytotoxic chemotherapy. However, preclinical and clinical studies suggest that anti-VEGF therapy using bevacizumab may also lead to a pro-migratory phenotype in therapy resistant glioblastomas and thus actively promote tumor invasion and recurrent tumor growth. This review focusses on (1) mechanisms of tumor angiogenesis in human malignant glioma that are of particular relevance for targeted therapy and (2) controversial issues in tumor angiogenesis such as cancer stem-like cell-derived vasculogenesis and bone-marrow-derived vasculogenesis.

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Metadaten
Author:Karl PlateGND, Alexander Scholz, Daniel J. Dumont
URN:urn:nbn:de:hebis:30:3-300996
DOI:https://doi.org/10.1007/s00401-012-1066-5
ISSN:1432-0533
ISSN:0001-6322
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/23143192
Parent Title (English):Acta neuropathologica
Publisher:Springer
Place of publication:Berlin ; Heidelberg
Document Type:Article
Language:English
Year of Completion:2013
Date of first Publication:2012/11/11
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2013/06/21
Volume:124
Issue:6
Page Number:13
First Page:763
Last Page:775
Note:
Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited
HeBIS-PPN:347153941
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 3.0