Paraneoplastic cerebellar degeneration associated with lymphoepithelial carcinoma of the tonsil

Background: Paraneoplastic cerebellar degeneration (PCD) is a classical tumor-associated, immune-mediated disease typically associated with gynecological malignancies, small-cell lung-cancer or lymphoma.
Case presentati
Background: Paraneoplastic cerebellar degeneration (PCD) is a classical tumor-associated, immune-mediated disease typically associated with gynecological malignancies, small-cell lung-cancer or lymphoma.
Case presentation: Here we present the case of a 38-year old male with an over 12 months rapidly progressive cerebellar syndrome. Extensive diagnostic workup revealed selective hypermetabolism of the right tonsil in whole-body PET. Histological examination after tonsillectomy demonstrated a lymphoepithelial carcinoma of the tonsil and the tongue base strongly suggesting a paraneoplastic cause of the cerebellar syndrome. To the best of our knowledge this is the first case of an association of a lymphoepithelial carcinoma, a rare pharyngeal tumor, with PCD.
Conclusions: In cases of classical paraneoplastic syndromes an extensive search for neoplasms should be performed including whole-body PET to detect tumors early in the course of the disease.
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Author:Christian Henke, Johannes Rieger, Sylvia Hartmann, Marcus Middendorp, Helmuth Steinmetz, Ulf Ziemann
URN:urn:nbn:de:hebis:30:3-318790
URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016266
DOI:http://dx.doi.org/10.1186/1471-2377-13-147
ISSN:1471-2377
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=24134642
Parent Title (English):BMC neurology
Publisher:BioMed Central ; Springer
Place of publication:London ; Berlin ; Heidelberg
Document Type:Article
Language:English
Date of Publication (online):2013/10/31
Date of first Publication:2013/10/17
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2013/10/31
Tag:Lymphoepithelioma; PET; Paraneoplastic syndrome; Subacute cerebellar degeneration; Tonsil
Volume:13
Issue:147
Pagenumber:4
First Page:1
Last Page:4
Note:
© 2013 Henke et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
HeBIS PPN:362943893
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 2.0

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