Pheochromocytoma (PC12) cell response on mechanobactericidal titanium surfaces

Titanium is a biocompatible material that is frequently used for making implantable medical devices. Nanoengineering of the surface is the common method for increasing material biocompatibility, and while the nanostructu
Titanium is a biocompatible material that is frequently used for making implantable medical devices. Nanoengineering of the surface is the common method for increasing material biocompatibility, and while the nanostructured materials are well-known to represent attractive substrata for eukaryotic cells, very little information has been documented about the interaction between mammalian cells and bactericidal nanostructured surfaces. In this study, we investigated the effect of bactericidal titanium nanostructures on PC12 cell attachment and differentiation—a cell line which has become a widely used in vitro model to study neuronal differentiation. The effects of the nanostructures on the cells were then compared to effects observed when the cells were placed in contact with non-structured titanium. It was found that bactericidal nanostructured surfaces enhanced the attachment of neuron-like cells. In addition, the PC12 cells were able to differentiate on nanostructured surfaces, while the cells on non-structured surfaces were not able to do so. These promising results demonstrate the potential application of bactericidal nanostructured surfaces in biomedical applications such as cochlear and neuronal implants.
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Metadaten
Author:Jason V. Wandiyanto, Denver Linklater, Pallale Tharushi Perera, Anna Orlowska, Vi Khanh Truong, Helmut Thissen, Shahram Ghanaati, Vladimir Baulin, Russell J. Crawford, Saulius Juodkazis, Elena P. Ivanova
URN:urn:nbn:de:hebis:30:3-338187
DOI:http://dx.doi.org/10.3390/ma11040605
ISSN:1996-1944
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=29662020
Parent Title (English):Materials
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Year of Completion:2018
Date of first Publication:2018/04/14
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/04/24
Tag:PC12 cells; mechanobactericidal surfaces; nanostructures; titanium
Volume:11
Issue:4, Art. 605
Pagenumber:13
First Page:1
Last Page:13
Note:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
HeBIS PPN:432027475
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0

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