The architect who never sleeps : tumor-induced plasticity
- Tumor cell plasticity is an event that has been observed in several malignancies. In fact, most of the solid tumors are characterized by cellular heterogeneity and undergo constant changes as the tumor develops. The increased plasticity displayed by these cells allows them to acquire additional properties, enabling epithelial-mesenchymal transitions, dedifferentiation and the acquisition of stem cell-like properties. Here we discuss the particular importance of an inflammatory microenvironment for the bidirectional control of cellular plasticity and the potential for therapeutic intervention.
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| Author: | Julia Varga, Tiago de Oliveira, Florian GretenORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-352626 |
| DOI: | https://doi.org/10.1016/j.febslet.2014.06.019 |
| ISSN: | 1873-3468 |
| ISSN: | 0014-5793 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/24931375 |
| Parent Title (English): | FEBS letters |
| Publisher: | Elsevier |
| Place of publication: | Amsterdam [u.a.] |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2014/06/12 |
| Date of first Publication: | 2014/06/12 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2014/11/25 |
| Tag: | Cancer; Cell plasticity; Tumor microenvironment |
| Volume: | 588 |
| Issue: | 15 |
| Page Number: | 6 |
| First Page: | 2422 |
| Last Page: | 2427 |
| Note: | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
| HeBIS-PPN: | 367092654 |
| Institutes: | Medizin / Medizin |
| Angeschlossene und kooperierende Institutionen / Georg-Speyer-Haus | |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0 |
