Association of myeloperoxidase with total and cardiovascular mortality in individuals undergoing coronary angiography : the LURIC study

Background: The phagocytic enzyme myeloperoxidase (MPO) acts as a front-line defender against microorganisms. However, increased MPO levels have been found to be associated with complex and calcified atherosclerotic lesi
Background: The phagocytic enzyme myeloperoxidase (MPO) acts as a front-line defender against microorganisms. However, increased MPO levels have been found to be associated with complex and calcified atherosclerotic lesions and incident cardiovascular disease. Therefore, this study aimed to investigate a predictive role of MPO, a biomarker of inflammation and oxidative stress, for total and cardiovascular mortality in patients referred to coronary angiography.
Methods and results: MPO plasma concentrations along with eight MPO polymorphisms were determined in 3036 participants of the Ludwigshafen Risk and Cardiovascular Health study (median follow-up 7.75 years). MPO concentrations were positively associated with age, diabetes, smoking, markers of systemic inflammation (interleukin-6, fibrinogen, C-reactive protein, serum amyloid A) and vascular damage (vascular cellular adhesion molecule-1 and intercellular adhesion molecule-1) but negatively associated with HDL-cholesterol and apolipoprotein A-I. After adjustment for cardiovascular risk factors MPO concentrations in the highest versus the lowest quartile were associated with a 1.34-fold risk (95% CI: 1.09–1.67) for total mortality. In the adjusted model the hazard ratio for cardiovascular mortality in the highest MPO quartile was 1.42 (95% CI: 1.07–1.88). Five MPO polymorphisms were positively associated with MPO concentrations but not with mortality. Using Mendelian randomization, we did not obtain evidence for a causal association of MPO with either total or cardiovascular mortality.
Conclusions: MPO concentrations but not genetic variants at the MPO locus are independently associated with risk for total and cardiovascular mortality in coronary artery disease patients.
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Author:Hubert Scharnagl, Marcus E. Kleber, Bernd Genser, Sandra Kickmaier, Wilfried Renner, Gisela Weihrauch, Tanja Grammer, Christine Rossmann, Bernhard R. Winkelmann, Bernhard O. Böhm, Wolfgang Sattler, Winfried März, Ernst Malle
URN:urn:nbn:de:hebis:30:3-364760
DOI:http://dx.doi.org/10.1016/j.ijcard.2014.03.168
ISSN:0167-5273
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=24746542
Parent Title (English):International journal of cardiology
Publisher:Elsevier Science
Place of publication:Amsterdam [u.a.]
Document Type:Article
Language:English
Date of Publication (online):2015/01/16
Date of first Publication:2014/04/03
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2015/01/16
Tag:Cardiovascular mortality; High-density lipoprotein; Inflammation; Myeloperoxidase; Risk factor
Volume:174
Issue:1
Pagenumber:10
First Page:96
Last Page:105
Note:
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
HeBIS PPN:367498901
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0

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