Risk stratification for sudden cardiac death : current status and challenges for the future

  • Sudden cardiac death (SCD) remains a daunting problem. It is a major public health issue for several reasons: from its prevalence (20% of total mortality in the industrialized world) to the devastating psycho-social impact on society and on the families of victims often still in their prime, and it represents a challenge for medicine, and especially for cardiology. This text summarizes the discussions and opinions of a group of investigators with a long-standing interest in this field. We addressed the occurrence of SCD in individuals apparently healthy, in patients with heart disease and mild or severe cardiac dysfunction, and in those with genetically based arrhythmic diseases. Recognizing the need for more accurate registries of the global and regional distribution of SCD in these different categories, we focused on the assessment of risk for SCD in these four groups, looking at the significance of alterations in cardiac function, of signs of electrical instability identified by ECG abnormalities or by autonomic tests, and of the progressive impact of genetic screening. Special attention was given to the identification of areas of research more or less likely to provide useful information, and thereby more or less suitable for the investment of time and of research funds.

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Metadaten
Author:Hein J. J. Wellens, Peter J. Schwartz, Fred W. Lindemans, Alfred E. Buxton, Jeffrey J. Goldberger, Stefan H. HohnloserORCiD, Heikki V. Huikuri, Stefan KääbORCiD, Maria Teresa La Rovere, Marek Malik, Robert J. Myerburg, Maarten L. Simoons, Karl Swedberg, Jan Tijssen, Adriaan A. Voors, Arthur A. Wilde
URN:urn:nbn:de:hebis:30:3-371777
DOI:https://doi.org/10.1093/eurheartj/ehu176
ISSN:1522-9645
ISSN:0195-668X
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/24801071
Parent Title (English):European heart journal
Publisher:Oxford Univ. Press
Place of publication:Oxford
Document Type:Article
Language:English
Year of Completion:2015
Date of first Publication:2014/05/06
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2015/03/22
Tag:Genetics
Autonomic nervous system; Cardiac function; Electrical instability; Risk stratification; Sudden cardiac death
Volume:35
Issue:25
Page Number:13
First Page:1642
Last Page:1651
Note:
Copyright © The Author 2014. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact
HeBIS-PPN:368920836
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell 3.0