Tricyclic guanidine alkaloids from the marine sponge Acanthella cavernosa that stabilize the tumor suppressor PDCD4

  • A cell-based high-throughput screen that assessed the cellular stability of a tumor suppressor protein PDCD4 (Programmed cell death 4) was used to identify a new guanidine-containing marine alkaloid mirabilin K (3), as well as the known compounds mirabilin G (1) and netamine M (2). The structures of these tricyclic guanidine alkaloids were established from extensive spectroscopic analyses. Compounds 1 and 2 inhibited cellular degradation of PDCD4 with EC50 values of 1.8 μg/mL and 2.8 μg/mL, respectively. Mirabilin G (1) and netamine M (2) are the first marine natural products reported to stabilize PDCD4 under tumor promoting conditions.

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Author:Tanja Grkovic, Johanna S. Blees, Magdalena M. Bayer, Nancy H. Colburn, Cheryl L. Thomas, Curtis J. Henrich, Megan L. Peach, James B. McMahon, Tobias SchmidORCiDGND, Kirk R. GustafsonORCiD
URN:urn:nbn:de:hebis:30:3-372435
DOI:https://doi.org/10.3390/md12084593
ISSN:1660-3397
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/25196934
Parent Title (English):Marine drugs
Publisher:Molecular Diversity Preservation International
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2014/08/21
Date of first Publication:2014/08/21
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2015/04/29
Tag:PDCD4; guanidine alkaloid; natural product; tumor suppressor
Volume:12
Issue:8
Page Number:9
First Page:4593
Last Page:4601
Note:
Copyright © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
HeBIS-PPN:369051610
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 3.0

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