Nox4 is dispensable for exercise induced muscle fibre switch

Introduction: By producing H2O2, the NADPH oxidase Nox4 is involved in differentiation of mesenchymal cells. Exercise alters the composition of slow and fast twitch fibres in skeletal. Here we hypothesized that Nox4 cont
Introduction: By producing H2O2, the NADPH oxidase Nox4 is involved in differentiation of mesenchymal cells. Exercise alters the composition of slow and fast twitch fibres in skeletal. Here we hypothesized that Nox4 contributes to exercise-induced adaptation such as changes in muscle metabolism or muscle fibre specification and studied this in wildtype and Nox4-/- mice.
Results: Exercise, as induced by voluntary running in a running wheel or forced running on a treadmill induced a switch from fast twitch to intermediate fibres. However the induced muscle fibre switch was similar between Nox4-/- and wildtype mice. The same held true for exercise-induced expression of PGC1α or AMPK activation. Both are increased in response to exercise, but with no difference was observed between wildtype and Nox4-/- mice.
Conclusion: Thus, exercise-induced muscle fibre switch is Nox4-independent.
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Metadaten
Author:Juri Vogel, Flávia Figueiredo de Rezende Felipe, Susanne Rohrbach, Min Zhang, Katrin Schröder
URN:urn:nbn:de:hebis:30:3-379994
DOI:http://dx.doi.org/10.1371/journal.pone.0130769
ISSN:1932-6203
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=26083642
Parent Title (English):PLoS One
Publisher:PLoS
Place of publication:Lawrence, Kan.
Document Type:Article
Language:English
Date of Publication (online):2015/06/17
Date of first Publication:2015/06/17
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2015/09/06
Volume:10
Issue:(6): e0130769
Pagenumber:10
First Page:1
Last Page:10
Note:
Copyright: © 2015 Vogel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
HeBIS PPN:370775031
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0

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