A general homeostatic principle following lesion induced dendritic remodeling

Introduction: Neuronal death and subsequent denervation of target areas are hallmarks of many neurological disorders. Denervated neurons lose part of their dendritic tree, and are considered "atrophic", i.e. pathological
Introduction: Neuronal death and subsequent denervation of target areas are hallmarks of many neurological disorders. Denervated neurons lose part of their dendritic tree, and are considered "atrophic", i.e. pathologically altered and damaged. The functional consequences of this phenomenon are poorly understood.
Results: Using computational modelling of 3D-reconstructed granule cells we show that denervation-induced dendritic atrophy also subserves homeostatic functions: By shortening their dendritic tree, granule cells compensate for the loss of inputs by a precise adjustment of excitability. As a consequence, surviving afferents are able to activate the cells, thereby allowing information to flow again through the denervated area. In addition, action potentials backpropagating from the soma to the synapses are enhanced specifically in reorganized portions of the dendritic arbor, resulting in their increased synaptic plasticity. These two observations generalize to any given dendritic tree undergoing structural changes.
Conclusions: Structural homeostatic plasticity, i.e. homeostatic dendritic remodeling, is operating in long-term denervated neurons to achieve functional homeostasis.
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Author:Steffen Platschek, Hermann Cuntz, Mario Vuksic, Thomas Deller, Peter Jedlicka
URN:urn:nbn:de:hebis:30:3-416783
DOI:http://dx.doi.org/10.1186/s40478-016-0285-8
ISSN:2051-5960
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=26916562
Parent Title (English):Acta Neuropathologica Communications
Document Type:Article
Language:English
Date of Publication (online):2016/02/25
Date of first Publication:2016/02/25
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2016/10/17
Tag:Backpropagating action potential; Compartmental modeling; Computer simulation; Electrotonic analysis; Granule cell; Homeostatic plasticity; Morphological modeling; Voltage attenuation
Volume:4
Issue:19
Pagenumber:11
First Page:1
Last Page:11
Note:
© 2016 Platschek et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
HeBIS PPN:399785353
Institutes:Medizin
Frankfurt Institute for Advanced Studies (FIAS)
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0

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