Karyotype complexity and prognosis in acute myeloid leukemia

  • A complex aberrant karyotype consisting of multiple unrelated cytogenetic abnormalities is associated with poor prognosis in patients with acute myeloid leukemia (AML). The European Leukemia Net classification and the UK Medical Research Council recommendation provide prognostic categories that differ in the definition of unbalanced aberrations as well as the number of single aberrations. The aim of this study on 3526 AML patients was to redefine and validate a cutoff for karyotype complexity in AML with regard to adverse prognosis. Our study demonstrated that (1) patients with a pure hyperdiploid karyotype have an adverse risk irrespective of the number of chromosomal gains, (2) patients with translocation t(9;11)(p21~22;q23) have an intermediate risk independent of the number of additional aberrations, (3) patients with greater than or equal to4 abnormalities have an adverse risk per se and (4) patients with three aberrations in the absence of abnormalities of strong influence (hyperdiploid karyotype, t(9;11)(p21~22;q23), CBF-AML, unique adverse-risk aberrations) have borderline intermediate/adverse risk with a reduced overall survival compared with patients with a normal karyotype.

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Author:Friedrich StölzelORCiDGND, Brigitte Mohr, Michael Kramer, Uta Oelschlägel, Tilmann Bochtler, Wolfgang E. Berdel, Martin Kaufmann, Claudia BaldusORCiDGND, Kerstin Schäfer-Eckart, Reingard Stuhlmann, Hermann EinseleORCiDGND, Stefan W. KrauseORCiDGND, Hubert ServeORCiDGND, Mathias Hänel, Regina Herbst, Andreas NeubauerORCiD, Kristina Sohlbach, Jiri Mayer, Jan Moritz Middeke, Uwe PlatzbeckerORCiDGND, Markus Schaich, Alwin KrämerORCiDGND, Christoph Röllig, Johannes Schetelig, Martin Bornhäuser, Gerhard EhningerGND
URN:urn:nbn:de:hebis:30:3-417198
DOI:https://doi.org/10.1038/bcj.2015.114
ISSN:2044-5385
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/26771812
Parent Title (English):Blood cancer journal
Publisher:Nature Publishing Group
Place of publication:London [u.a.]
Document Type:Article
Language:English
Year of Completion:2016
Date of first Publication:2016/01/15
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2016/10/21
Volume:6
Issue:e386
Page Number:7
Note:
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
HeBIS-PPN:424818647
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0