The role of cGMP and PKG-I in spinal nociceptive processing
First paragraph (this article has no abstract) Persistent stimulation of nociceptors results in sensitization of nociceptive sensory neurons, which is associated with hyperalgesia and allodynia. The release of NO and subsequent synthesis of cGMP in the spinal cord are involved in this process. cGMP-dependent protein kinase I (PKG-I) has been suggested to act as a downstream target of cGMP, but its exact role in nociception hadn't been characterized yet. To further evaluate the NO/cGMP/PKG-I pathway in nociception we assessed the effects of PKG-I inhibiton and activaton in the rat formalin assay and analyzed the nociceptive behavior of PKG-I-/- mice. Open access article.
| Author: | Achim Schmidtko, Irmgard Tegeder, Ellen Niederberger, Franz Hofmann, Peter Ruth, Gerd Geisslinger |
|---|---|
| URN: | urn:nbn:de:hebis:30-11521 |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 22.06.2005 |
| Year of first Publication: | 2005 |
| Publishing Institution: | Univ.-Bibliothek Frankfurt am Main |
| Source: | BMC Pharmacology 2005, 5(Suppl 1):P50 , http://www.biomedcentral.com/content/pdf/1471-2210-5-S1-P50.pdf |
| HeBIS PPN: | 191141569 |
| Institutes: | Pharmazie |
| Dewey Decimal Classification: | 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Veröffentlichungsvertrag für Publikationen ohne Print on Demand |
