Severe infection with multidrug-resistant Salmonella choleraesuis in a young patient with primary sclerosing cholangitis

Massive global spread of multidrug-resistant (MDR) Salmonella spp. expressing extended-spectrum beta-lactamase (ESBL) and additional resistance to fluoroquinolones has often been attributed to high international mobility
Massive global spread of multidrug-resistant (MDR) Salmonella spp. expressing extended-spectrum beta-lactamase (ESBL) and additional resistance to fluoroquinolones has often been attributed to high international mobility as well as excessive use of oral antibiotics in livestock farming. However, MDR Salmonella spp. have not been mentioned as a widespread pathogen in clinical settings so far. We demonstrate the case of a 25-year-old male with primary sclerosing cholangitis who tested positive for MDR Salmonella enterica serotype Choleraesuis expressing ESBL and fluoroquinolone resistance. The pathogen was supposedly acquired during a trip to Thailand, causing severe fever, cholangitis and pancreatitis. To our knowledge, this is the first report of Salmonella enterica serotype Choleraesuis in Europe expressing such a multidrug resistance pattern. ESBL resistance of Salmonella enterica spp. should be considered in patients with obstructive biliary tract pathology and travel history in endemic countries.
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Author:Philip Ferstl, Claudia Reinheimer, Katalin Jozsa, Stefan Zeuzem, Volkhard A. J. Kempf, Oliver Waidmann, Georgios Grammatikos
URN:urn:nbn:de:hebis:30:3-441308
DOI:http://dx.doi.org/10.3748/wjg.v23.i11.2086
ISSN:2219-2840
ISSN:1007-9327
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=28373776
Parent Title (English):World journal of gastroenterology
Publisher:WJG Press
Place of publication:Beijing
Document Type:Article
Language:English
Date of Publication (online):2017/04/06
Date of first Publication:2017/03/21
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2017/04/06
Tag:Biliary physiology; Infectious disease; Multidrug resistance; Primary sclerosing cholangitis; Salmonella choleraesuis
Volume:23
Issue:11
Pagenumber:5
First Page:2086
Last Page:2089
Note:
Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
HeBIS PPN:421389737
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (English):License LogoCreative Commons - Namensnennung-Nicht kommerziell 4.0

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