Autophagy compensates impaired energy metabolism in CLPXP‐deficient Podospora anserina strains and extends healthspan

The degradation of nonfunctional mitochondrial proteins is of fundamental relevance for maintenance of cellular homeostasis. The heteromeric CLPXP protein complex in the mitochondrial matrix is part of this process. In t
The degradation of nonfunctional mitochondrial proteins is of fundamental relevance for maintenance of cellular homeostasis. The heteromeric CLPXP protein complex in the mitochondrial matrix is part of this process. In the fungal aging model Podospora anserina, ablation of CLPXP leads to an increase in healthy lifespan. Here, we report that this counterintuitive increase depends on a functional autophagy machinery. In PaClpXP mutants, autophagy is involved in energy conservation and the compensation of impairments in respiration. Strikingly, despite the impact on mitochondrial function, it is not mitophagy but general autophagy that is constitutively induced and required for longevity. In contrast, in another long-lived mutant ablated for the mitochondrial PaIAP protease, autophagy is neither induced nor required for lifespan extension. Our data provide novel mechanistic insights into the capacity of different forms of autophagy to compensate impairments of specific components of the complex mitochondrial quality control network and about the biological role of mitochondrial CLPXP in the control of cellular energy metabolism.
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Metadaten
Author:Laura Knuppertz, Heinz D. Osiewacz
URN:urn:nbn:de:hebis:30:3-452246
DOI:http://dx.doi.org/10.1111/acel.12600
ISSN:1474-9728
ISSN:1474-9718
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=28449241
Parent Title (English):Aging cell
Publisher:Wiley-Blackwell
Place of publication:Oxford [u. a.]
Document Type:Article
Language:English
Year of Completion:2017
Date of first Publication:2017/04/27
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2017/12/14
Tag:CLPXP protease; Podospora anserina; aging; autophagy; energy metabolism; mitochondria
Volume:16
Issue:4
Pagenumber:12
First Page:704
Last Page:715
Note:
© 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
HeBIS PPN:451939468
Institutes:Biowissenschaften
Exzellenzcluster Makromolekulare Komplexe
Dewey Decimal Classification:570 Biowissenschaften; Biologie
Sammlungen:Universitätspublikationen
Open-Access-Publikationsfonds:Biowissenschaften
Licence (German):License LogoCreative Commons - Namensnennung 4.0

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