Chemoradiotherapy as definitive treatment for elderly patients with head and neck cancer

Background: With the aging population and a rising incidence of squamous cell carcinoma of the head and neck (SCCHN), there is an emerging need for developing strategies to treat elderly patients.
Patients and Methods: 
Background: With the aging population and a rising incidence of squamous cell carcinoma of the head and neck (SCCHN), there is an emerging need for developing strategies to treat elderly patients.
Patients and Methods: We retrospectively analyzed 158 patients treated with definitive, concurrent chemoradiotherapy (CRT) for SCCHN. Clinicopathological characteristics, acute toxicities, and oncological outcomes were compared between patients younger and older than (or of age equal to) 65, 70, and 75 years.
Results: RT dose, chemotherapy regimen, and total chemotherapy dose were balanced between the groups. After a median follow-up of 29 months, overall survival (OS), progression-free survival (PFS), local control rate, and distant metastasis-free survival stratified by age of ≥65, ≥70, or ≥75 years revealed no differences. The rate of acute toxicities was also not higher for older patients. Worse ECOG performance score (ECOG 2-3) was associated with impaired OS () and PFS ().
Conclusion: Definitive treatment with CRT for SCCHN is feasible and effective; even in advanced age treatment decisions should be made according to general condition and comorbidity, rather than calendar age alone.
show moreshow less

Export metadata

  • Export Bibtex
  • Export RIS
Metadaten
Author:Jens Müller-von der Grün, Daniel Martin, Timo Stöver, Shahram Ghanaati, Claus Rödel, Panagiotis Balermpas
URN:urn:nbn:de:hebis:30:3-469684
DOI:http://dx.doi.org/10.1155/2018/3508795
ISSN:2314-6141
ISSN:2314-6133
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=29581971
Parent Title (English):BioMed research international
Publisher:Hindawi
Place of publication:New York [u. a.]
Contributor(s):Nam Nguyen
Document Type:Article
Language:English
Year of Completion:2018
Date of first Publication:2018/01/17
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/09/18
Volume:2018
Issue:Art. 3508795
Pagenumber:10
First Page:1
Last Page:9
Note:
Copyright © 2018 Jens Müller von der Grün et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
HeBIS PPN:437849805
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0

$Rev: 11761 $