Redox regulation beyond ROS : why ROS should not be measured as often
- Based on the concept of oxidative stress, reactive oxygen species (ROS) have been incriminated as the drivers behind almost every cardiovascular pathology. Redox alterations are, however, omnipresent bystanders to changes in cellular activity state. Even when ROS levels are altered, their contribution to pathology is not necessarily causal. Researchers should hesitate to engage in global ROS measurements and rather aim on identifying individual molecular targets of redox regulation.
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| Author: | Ralf BrandesORCiDGND, Flávia Figueiredo de Rezende FelipeORCiDGND, Katrin SchröderORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-471697 |
| DOI: | https://doi.org/10.1161/CIRCRESAHA.118.313146 |
| ISSN: | 1524-4571 |
| ISSN: | 0009-7330 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/30026378 |
| Parent Title (English): | Circulation research |
| Publisher: | Assoc. |
| Place of publication: | New York, NY |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2018 |
| Date of first Publication: | 2018/07/19 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2018/09/04 |
| Tag: | antioxidants; cardiovascular diseases; cytokines; oxygen; reactive oxygen species |
| Volume: | 123 |
| Issue: | 3 |
| Page Number: | 3 |
| First Page: | 326 |
| Last Page: | 328 |
| Note: | © 2018 The Authors. Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made. |
| HeBIS-PPN: | 437850900 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |
