Redox regulation beyond ROS : why ROS should not be measured as often

Based on the concept of oxidative stress, reactive oxygen species (ROS) have been incriminated as the drivers behind almost every cardiovascular pathology. Redox alterations are, however, omnipresent bystanders to change
Based on the concept of oxidative stress, reactive oxygen species (ROS) have been incriminated as the drivers behind almost every cardiovascular pathology. Redox alterations are, however, omnipresent bystanders to changes in cellular activity state. Even when ROS levels are altered, their contribution to pathology is not necessarily causal. Researchers should hesitate to engage in global ROS measurements and rather aim on identifying individual molecular targets of redox regulation.
show moreshow less

Metadaten
Author:Ralf Peter Louis Brandes, Flavia Rezende, Katrin Schröder
URN:urn:nbn:de:hebis:30:3-471697
DOI:http://dx.doi.org/10.1161/CIRCRESAHA.118.313146
ISSN:1524-4571
ISSN:0009-7330
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=30026378
Parent Title (English):Circulation research
Publisher:Assoc.
Place of publication:New York, NY
Document Type:Article
Language:English
Year of Completion:2018
Date of first Publication:2018/07/19
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/09/04
Tag:antioxidants; cardiovascular diseases; cytokines; oxygen; reactive oxygen species
Volume:123
Issue:3
Pagenumber:3
First Page:326
Last Page:328
Note:
© 2018 The Authors. Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.
HeBIS PPN:437850900
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0

$Rev: 11761 $