Lymphangioleiomyomatosis : a case report and review of diagnosis and treatment

Lymphangioleiomyomatosis (LAM) is a rare disease that generally affects young women and involves the abnormal proliferation of smooth muscle-like cells (LAM cells) in the lungs (pulmonary LAM) and extrapulmonary sites (e
Lymphangioleiomyomatosis (LAM) is a rare disease that generally affects young women and involves the abnormal proliferation of smooth muscle-like cells (LAM cells) in the lungs (pulmonary LAM) and extrapulmonary sites (extrapulmonary LAM). This disease is rare in males. It is hard to distinguish between lung cancer and pulmonary LAM, especially during early stages. Herein, we present a case of a 66-year-old man with a small nodule in the right upper lobe that was first diagnosed as a lung malignancy using a chest CT scan. After a wedge dissection, a pathologist performed a histologic and immunohistochemical examination, and a diagnosis of pulmonary LAM was made. We further performed a 518-gene panel analysis using next-generation sequencing, and only three genes, BARD1, BLM, and BRCA2, were found to have mutations. We also provide a summary of the diagnosis and treatment of this disease.
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Metadaten
Author:Yi Liu, Zhibin Guo, Chenlong Zhao, Xin Li, Hongyu Liu, Jun Chen
URN:urn:nbn:de:hebis:30:3-484371
DOI:http://dx.doi.org/10.2147/OTT.S161360
ISSN:1178-6930
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=30214240
Parent Title (English):OncoTargets and therapy
Publisher:Dove Medical Press
Place of publication:Albany, Auckland
Contributor(s):Geoffrey Pietersz
Document Type:Article
Language:English
Year of Completion:2018
Date of first Publication:2018/08/31
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/03/07
Tag:diagnosis and treatment; lung cancer; lymphangioleiomyomatosis
Volume:11
Pagenumber:9
First Page:5339
Last Page:5347
Note:
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.
HeBIS PPN:448056844
Institutes:Extern
Dewey Decimal Classification:610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung 3.0

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