Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila

The repeated and improper use of antibiotics had led to an increased number of multiresistant bacteria. Therefore, new lead structures are needed. Here, the synthesis and an expanded structure–activity relationship of th
The repeated and improper use of antibiotics had led to an increased number of multiresistant bacteria. Therefore, new lead structures are needed. Here, the synthesis and an expanded structure–activity relationship of the simple and antistaphylococcal amide nematophin from Xenorhabdus nematophila and synthetic derivatives are described. Moreover, the synthesis of intrinsic fluorescent derivatives, incorporating azaindole moieties was achieved for the first time.
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Metadaten
Author:Frank Wesche, Hélène Adihou, Thomas Alexander Wichelhaus, Helge Björn Bode
URN:urn:nbn:de:hebis:30:3-488112
DOI:http://dx.doi.org/10.3762/bjoc.15.47
ISSN:1860-5397
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=30873237
Parent Title (English):Beilstein journal of organic chemistry
Publisher:Beilstein-Institut zur Förderung der Chemischen Wissenschaften
Place of publication:Frankfurt, Main
Contributor(s):J. S. Dickschat
Document Type:Article
Language:English
Year of Completion:2019
Date of first Publication:2019/02/25
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/04/02
Tag:MRSA; Staphylococcus aureus; azaindole; fluorescent dye; nematophin
Volume:15
Pagenumber:7
First Page:535
Last Page:541
Note:
This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc)
HeBIS PPN:447589326
Institutes:Biowissenschaften
Medizin
Dewey Decimal Classification:570 Biowissenschaften; Biologie
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0

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