Performance and impact of prostate specific membrane antigen-based diagnostics in the management of men with biochemical recurrence of prostate cancer and its role in salvage lymph node dissection

Up to 50% of patients initially treated for prostate cancer in a curative intent experience biochemical recurrence, possibly requiring adjuvant treatment. However, salvage treatment decisions, such as lymph node dissecti
Up to 50% of patients initially treated for prostate cancer in a curative intent experience biochemical recurrence, possibly requiring adjuvant treatment. However, salvage treatment decisions, such as lymph node dissection or radiation therapy, are typically based on prostate specific antigen (PSA) recurrence. Importantly, common imaging modalities (e.g., computed tomography [CT], magnetic resonance imaging, and bone scan) are limited and the detection of recurrent disease is particularly challenging if PSA is low. Prostate specific membrane antigen (PSMA) positron-emission tomography/computed tomography (PET/CT) is a novel and promising imaging modality which aims to overcome the incapability of early identification of distant and regional metastases. Within this review, we summarize the current evidence related to PSMA-PET/CT in prostate cancer men diagnosed with biochemical recurrence after local treatment with curative intent. We discuss detection rates of PSMA-PET/CT stratified by PSA-levels and its impact on clinical decision making. Furthermore, we compare different imagefusion techniques such as PSMA-PET vs. F-/C-Choline-PET scans vs. PSMA-single photon emission computed tomography/CT. Finally, we touch upon the contemporary role of radio-guided-PSMA salvage lymphadenectomy.
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Metadaten
Author:Marieke Johanna Krimphove, Lena Theißen, Alexander P. Cole, Felix Martin Preißer, Philipp Cornelius Mandel, Felix Chun
URN:urn:nbn:de:hebis:30:3-488373
DOI:http://dx.doi.org/10.5534/wjmh.180133
ISSN:2287-4690
ISSN:2287-4208
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=30929322
Parent Title (English):The world journal of men's health
Publisher:Korean Society for Sexual Medicine and Andrology
Place of publication:Busan
Document Type:Article
Language:English
Year of Completion:2019
Date of first Publication:2019/03/05
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/04/04
Tag:Positron-emission tomography; Prostate-specific membrane antigen; Prostatic neoplasms; Salvage therapy; human
Volume:37
Issue:e9
Pagenumber:16
First Page:1
Last Page:16
Note:
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
HeBIS PPN:450809846
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (English):License LogoCreative Commons - Namensnennung-Nicht kommerziell 4.0

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