Oncogenic deregulation of cell adhesion molecules in leukemia

Numerous cell–cell and cell–matrix interactions within the bone marrow microenvironment enable the controlled lifelong self-renewal and progeny of hematopoietic stem and progenitor cells (HSPCs). On the cellular level, t
Numerous cell–cell and cell–matrix interactions within the bone marrow microenvironment enable the controlled lifelong self-renewal and progeny of hematopoietic stem and progenitor cells (HSPCs). On the cellular level, this highly mutual interaction is granted by cell adhesion molecules (CAMs) integrating differentiation, proliferation, and pro-survival signals from the surrounding microenvironment to the inner cell. However, cell–cell and cell–matrix interactions are also critically involved during malignant transformation of hematopoietic stem/progenitor cells. It has become increasingly apparent that leukemia-associated gene products, such as activated tyrosine kinases and fusion proteins resulting from chromosomal translocations, directly regulate the activation status of adhesion molecules, thereby directing the leukemic phenotype. These observations imply that interference with adhesion molecule function represents a promising treatment strategy to target pre-leukemic and leukemic lesions within the bone marrow niche. Focusing on myeloid leukemia, we provide a current overview of the mechanisms by which leukemogenic gene products hijack control of cellular adhesion to subsequently disturb normal hematopoiesis and promote leukemia development.
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Metadaten
Author:Roland Windisch, Nina Pirschtat, Christian Kellner, Linping Chen-Wichmann, Jörn Lausen, Andreas Humpe, Daniela Sandra Krause, Christian Wichmann
URN:urn:nbn:de:hebis:30:3-488740
DOI:http://dx.doi.org/10.3390/cancers11030311
ISSN:2072-6694
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=30841639
Parent Title (English):Cancers
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Year of Completion:2019
Date of first Publication:2019/03/05
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/03/28
Tag:CAM; adhesion; integrin; leukemia; oncogene
Volume:11
Issue:3, Art. 311
Pagenumber:18
First Page:1
Last Page:18
Note:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
HeBIS PPN: 448053683
Institutes:Biowissenschaften
Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0

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