Epidermal mTORC1 signaling contributes to the pathogenesis of psoriasis and could serve as a therapeutic target
- Although modern biologics targeting different inflammatory mediators show promising therapeutic success, comprehensive knowledge about the molecular events in psoriatic keratinocytes that contribute to the pathogenesis and could serve as therapeutic targets is still scarce. However, recent efforts to understand the deregulated signal transduction pathways have led to the development of small molecule inhibitors e.g., tofacitinib targeting the Jak/Stat cascade that opens additional therapeutic options. Recently, the PI3-K/Akt/mTOR signaling pathway has emerged as an important player in the control of epidermal homeostasis. This review summarizes the current knowledge on the role of this pathway in the pathogenesis of psoriasis, especially the epidermal manifestation of the disease and discusses current approaches to target the pathway therapeutically.
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| Author: | Claudia BürgerORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-492801 |
| DOI: | https://doi.org/10.3389/fimmu.2018.02786 |
| ISSN: | 1664-3224 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/30555471 |
| Parent Title (English): | Frontiers in immunology |
| Publisher: | Frontiers Media |
| Place of publication: | Lausanne |
| Contributor(s): | Eva Reali |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2018 |
| Date of first Publication: | 2018/11/30 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2019/03/05 |
| Tag: | keratinocytes; mTORC1; psoriasis; rapamycin; topical agent |
| Volume: | 9 |
| Issue: | Art. 2786 |
| Page Number: | 7 |
| First Page: | 1 |
| Last Page: | 7 |
| Note: | Copyright © 2018 Buerger. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| HeBIS-PPN: | 448049848 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Open-Access-Publikationsfonds: | Medizin |
| Licence (German): |  Creative Commons - Namensnennung 4.0 |
