Anti-VEGF for the management of diabetic macular edema

Diabetic retinopathy (DR) is an important cause of vision loss around the world, being the leading cause in the population between 20 and 60 years old. Among patients with DR, diabetic macular edema (DME) is the most fre
Diabetic retinopathy (DR) is an important cause of vision loss around the world, being the leading cause in the population between 20 and 60 years old. Among patients with DR, diabetic macular edema (DME) is the most frequent cause of vision impairment and represents a significant public health issue. Macular photocoagulation has been the standard treatment for this condition reducing the risk of moderate visual loss by approximately 50%. The role of vascular endothelial growth factor (VEGF) in DR and DME pathogenesis has been demonstrated in recent studies. This review addresses and summarizes data from the clinical trials that investigated anti-VEGF for the management of DME and evaluates their impact on clinical practice. The literature searches were conducted between August and October 2013 in PubMed and Cochrane Library with no date restrictions and went through the most relevant studies on pegaptanib, ranibizumab, bevacizumab, and aflibercept for the management of DME. The efficacy and safety of intravitreal anti-VEGF as therapy for DME have recently been proved by various clinical trials providing significantly positive visual and anatomical results. Regarding clinical practice, those outcomes have placed intravitreal injection of anti-VEGF as an option that must be considered for the treatment of DME.
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Author:Francisco R. Stefanini, Emmerson Badaro, Paulo Falabella, Michael Janusz Koss, Michel Eid Farah, Maurício Maia
URN:urn:nbn:de:hebis:30:3-505162
DOI:http://dx.doi.org/10.1155/2014/632307
ISSN:2314-8861
ISSN:2314-7156
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=24741610
Parent Title (English):Journal of Immunology Research
Publisher:Hindawi
Place of publication:New York, NY
Contributor(s):Joseph Fomusi Ndisang
Document Type:Article
Language:English
Year of Completion:2014
Date of first Publication:2014/02/05
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/08/01
Volume:2014
Issue:Art. 632307
Pagenumber:9
First Page:1
Last Page:8
Note:
Copyright © 2014 Francisco Rosa Stefanini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
HeBIS PPN:452969069
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 3.0

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