Limitations of serum ferritin in diagnosing iron deficiency in inflammatory conditions

Patients with inflammatory conditions such as inflammatory bowel disease (IBD), chronic heart failure (CHF), and chronic kidney disease (CKD) have high rates of iron deficiency with adverse clinical consequences. Under n
Patients with inflammatory conditions such as inflammatory bowel disease (IBD), chronic heart failure (CHF), and chronic kidney disease (CKD) have high rates of iron deficiency with adverse clinical consequences. Under normal circumstances, serum ferritin levels are a sensitive marker for iron status but ferritin is an acute-phase reactant that becomes elevated in response to inflammation, complicating the diagnosis. Proinflammatory cytokines also trigger an increase in hepcidin, which restricts uptake of dietary iron and promotes sequestration of iron by ferritin within storage sites. Patients with inflammatory conditions may thus have restricted availability of iron for erythropoiesis and other cell functions due to increased hepcidin expression, despite normal or high levels of serum ferritin. The standard threshold for iron deficiency (<30 μg/L) therefore does not apply and transferrin saturation (TSAT), a marker of iron availability, should also be assessed. A serum ferritin threshold of <100 μg/L or TSAT < 20% can be considered diagnostic for iron deficiency in CHF, CKD, and IBD. If serum ferritin is 100–300 μg/L, TSAT < 20% is required to confirm iron deficiency. Routine surveillance of serum ferritin and TSAT in these at-risk groups is advisable so that iron deficiency can be detected and managed.
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Author:Axel Uwe Dignass, Karima Farrag, Jürgen Stein
URN:urn:nbn:de:hebis:30:3-506498
DOI:http://dx.doi.org/10.1155/2018/9394060
ISSN:2314-5749
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=29744352
Parent Title (English):International journal of chronic diseases
Publisher:Hindawi
Place of publication:New York, NY [u. a.]
Contributor(s):José F. Téllez-Zenteno
Document Type:Article
Language:English
Year of Completion:2018
Date of first Publication:2018/03/18
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/08/15
Volume:2018
Issue:Art. 9394060
Pagenumber:12
First Page:1
Last Page:11
Note:
Copyright © 2018 Axel Dignass et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
HeBIS PPN:453938892
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0

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