Migration properties distinguish tumor cells of classical hodgkin lymphoma from anaplastic large cell lymphoma cells

Anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL) are lymphomas that contain CD30-expressing tumor cells and have numerous pathological similarities. Whereas ALCL is usually diagnosed at an advan
Anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL) are lymphomas that contain CD30-expressing tumor cells and have numerous pathological similarities. Whereas ALCL is usually diagnosed at an advanced stage, cHL more frequently presents with localized disease. The aim of the present study was to elucidate the mechanisms underlying the different clinical presentation of ALCL and cHL. Chemokine and chemokine receptor expression were similar in primary ALCL and cHL cases apart from the known overexpression of the chemokines CCL17 and CCL22 in the Hodgkin and Reed-Sternberg (HRS) cells of cHL. Consistent with the overexpression of these chemokines, primary cHL cases encountered a significantly denser T cell microenvironment than ALCL. Additionally to differences in the interaction with their microenvironment, cHL cell lines presented a lower and less efficient intrinsic cell motility than ALCL cell lines, as assessed by time-lapse microscopy in a collagen gel and transwell migration assays. We thus propose that the combination of impaired basal cell motility and differences in the interaction with the microenvironment hamper the dissemination of HRS cells in cHL when compared with the tumor cells of ALCL.
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Metadaten
Author:Olga Goncharova, Nadine Flinner, Julia Bein, Claudia Döring, Emmanuel Donnadieu, Sandy Rikirsch, Marco Herling, Ralf Küppers, Martin-Leo Hansmann, Sylvia Hartmann
URN:urn:nbn:de:hebis:30:3-510931
DOI:http://dx.doi.org/10.3390/cancers11101484
ISSN:2072-6694
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=31581676
Parent Title (English):Cancers
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Year of Completion:2019
Date of first Publication:2019/10/02
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/10/14
Tag:anaplastic large cell lymphoma; cell motility; chemokine receptors; classical Hodgkin lymphoma; dissemination; gene expression; image analysis; rosetting T cells; segmentation
Volume:11
Issue:10, Art. 1484
Pagenumber:16
First Page:1
Last Page:16
Note:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
HeBIS PPN:455327386
Institutes:Informatik
Medizin
Frankfurt Institute for Advanced Studies (FIAS)
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Open-Access-Publikationsfonds:Medizin
Licence (German):License LogoCreative Commons - Namensnennung 4.0

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