Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls

Introduction: The neurobiological mechanisms behind panic disorder with agoraphobia (PD/AG) are not completely explored. The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gen
Introduction: The neurobiological mechanisms behind panic disorder with agoraphobia (PD/AG) are not completely explored. The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gene (NPSR1) has repeatedly been associated with panic disorder and might partly drive function respectively dysfunction of the neural “fear network”. We aimed to investigate whether the NPSR1 T risk allele was associated with malfunctioning in a fronto-limbic network during the anticipation and perception of agoraphobia-specific stimuli.
Method: 121 patients with PD/AG and 77 healthy controls (HC) underwent functional magnetic resonance imaging (fMRI) using the disorder specific “Westphal-Paradigm”. It consists of neutral and agoraphobia-specific pictures, half of the pictures were cued to induce anticipatory anxiety.
Results: Risk allele carriers showed significantly higher amygdala activation during the perception of agoraphobia-specific stimuli than A/A homozygotes. A linear group x genotype interaction during the perception of agoraphobia-specific stimuli showed a strong trend towards significance. Patients with the one or two T alleles displayed the highest and HC with the A/A genotype the lowest activation in the inferior orbitofrontal cortex (iOFC).
Discussion: The study demonstrates an association of the NPSR1rs324981 genotype and the perception of agoraphobia-specific stimuli. These results support the assumption of a fronto-limbic dysfunction as an intermediate phenotype of PD/AG.
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Metadaten
Author:Johanna Gechter, Carolin Liebscher, Maximilian J. Geiger, André Wittmann, Florian Schlagenhauf, Ulrike Lüken, Hans-Ulrich Wittchen, Bettina Pfleiderer, Volker Arolt, Tilo Kircher, Benjamin Straube, Jürgen Deckert, Heike Weber, Martin J. Herrmann, Andreas Reif, Katharina Domschke, Andreas Ströhle
URN:urn:nbn:de:hebis:30:3-517991
DOI:http://dx.doi.org/10.1016/j.nicl.2019.102029
ISSN:2213-1582
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=31734525
Parent Title (English):NeuroImage: Clinical
Publisher:Elsevier
Place of publication:[Amsterdam u. a.]
Document Type:Article
Language:English
Year of Completion:2019
Date of first Publication:2019/10/21
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/12/02
Tag:Agoraphobia; Imaging genetics; NPSR1; Panic disorder; Westphal-Paradigm; fMRI
Volume:24
Issue:Art. 102029
Pagenumber:8
First Page:1
Last Page:8
Note:
© 2019 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
HeBIS PPN:459851233
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0

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