Aberrant epigenetic regulators control expansion of human CD34+ hematopoietic stem/progenitor cells

Transcription is a tightly regulated process ensuring the proper expression of numerous genes regulating all aspects of cellular behavior. Transcription factors regulate multiple genes including other transcription facto
Transcription is a tightly regulated process ensuring the proper expression of numerous genes regulating all aspects of cellular behavior. Transcription factors regulate multiple genes including other transcription factors that together control a highly complex gene network. The transcriptional machinery can be “hijacked” by oncogenic transcription factors, thereby leading to malignant cell transformation. Oncogenic transcription factors manipulate a variety of epigenetic control mechanisms to fulfill gene regulatory and cell transforming functions. These factors assemble epigenetic regulators at target gene promoter sequences, thereby disturbing physiological gene expression patterns. Retroviral vector technology and the availability of “healthy” human hematopoietic CD34+ progenitor cells enable the generation of pre-leukemic cell models for the analysis of aberrant human hematopoietic progenitor cell expansion mediated by leukemogenic transcription factors. This review summarizes recent findings regarding the mechanism by which leukemogenic gene products control human hematopoietic CD34+ progenitor cell expansion by disrupting the normal epigenetic program.
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Author:Farnaz Faridi, Kanagaraju Ponnusamy, Isabell Quagliano-Lo Coco, Linping Chen-Wichmann, Manuel Grez, Reinhard Henschler, Christian Wichmann
URN:urn:nbn:de:hebis:30:3-520383
DOI:http://dx.doi.org/10.3389/fgene.2013.00254
ISSN:1664-8021
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=24348510
Parent Title (English):Frontiers in genetics
Publisher:Frontiers Media
Place of publication:Lausanne
Document Type:Article
Language:English
Year of Completion:2013
Date of first Publication:2013/11/28
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/01/15
Tag:HSPC; RUNX1/ETO; epigenetics; leukemia; stem/progenitor cell expansion
Volume:4
Issue:Art. 254
Pagenumber:7
First Page:1
Last Page:7
Note:
Copyright © 2013 Faridi, Ponnusamy, Quagliano-Lo Coco, Chen-Wichmann, Grez, Henschler and Wichmann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
HeBIS PPN:459324896
Institutes:Medizin
Georg-Speyer-Haus
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 3.0

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