Histogram analysis and visual heterogeneity of diffusion-weighted imaging with apparent diffusion coefficient mapping in the prediction of molecular subtypes of invasive breast cancers

Objective. To investigate if histogram analysis and visually assessed heterogeneity of diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) mapping can predict molecular subtypes of invasive breast 
Objective. To investigate if histogram analysis and visually assessed heterogeneity of diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) mapping can predict molecular subtypes of invasive breast cancers.
Materials and Methods. In this retrospective study, 91 patients with invasive breast carcinoma who underwent preoperative magnetic resonance imaging (MRI) with DWI at our institution were included. Two radiologists delineated a 2-D region of interest (ROI) on ADC maps in consensus. Tumors were also independently classified into low and high heterogeneity based on visual assessment of DWI. First-order statistics extracted through histogram analysis within the ROI of the ADC maps (mean, 10th percentile, 50th percentile, 90th percentile, standard deviation, kurtosis, and skewness) and visually assessed heterogeneity were evaluated for associations with tumor receptor status (ER, PR, and HER2 status) as well as molecular subtype.
esults. HER2-positive lesions demonstrated significantly higher mean (), Perc50 (), and Perc90 (), with AUCs of 0.605, 0.592, and 0.652, respectively, than HER2-negative lesions. No significant differences were found in the histogram values for ER and PR statuses. Neither quantitative histogram analysis based on ADC maps nor qualitative visual heterogeneity assessment of DWI images was able to significantly differentiate between molecular subtypes, i.e., luminal A versus all other subtypes (luminal B, HER2-enriched, and triple negative) combined, luminal A and B combined versus HER2-enriched and triple negative combined, and triple negative versus all other types combined.
Conclusion. Histogram analysis and visual heterogeneity assessment cannot be used to differentiate molecular subtypes of invasive breast cancer.
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Author:Joao V. Horvat, Aditi Iyer, Elizabeth A. Morris, Aditya Apte, Blanca Bernard-Davila, Danny F. Martinez, Doris Leithner, Olivia M. Sutton, R. Elena Ochoa-Albiztegui, Dilip Giri, Katja Pinker, Sunitha B. Thakur
URN:urn:nbn:de:hebis:30:3-529961
DOI:http://dx.doi.org/10.1155/2019/2972189
ISSN:1555-4317
ISSN:1555-4309
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=31819738
Parent Title (English):Contrast media & molecular imaging
Publisher:Hindawi
Place of publication:London
Contributor(s):María Luisa García Martín
Document Type:Article
Language:English
Year of Completion:2019
Date of first Publication:2019/11/22
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/03/04
Volume:14
Issue:Art. 2972189
Pagenumber:10
First Page:1
Last Page:9
Note:
Copyright © 2019 Joao V. Horvat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
HeBIS PPN:461396408
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0

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