Macrophage and tumor cell cross-talk is fundamental for lung tumor progression: we need to talk

Regardless of the promising results of certain immune checkpoint blockers, current immunotherapeutics have met a bottleneck concerning response rate, toxicity, and resistance in lung cancer patients. Accumulating evidenc
Regardless of the promising results of certain immune checkpoint blockers, current immunotherapeutics have met a bottleneck concerning response rate, toxicity, and resistance in lung cancer patients. Accumulating evidence forecasts that the crosstalk between tumor and immune cells takes center stage in cancer development by modulating tumor malignancy, immune cell infiltration, and immune evasion in the tumor microenvironment (TME). Cytokines and chemokines secreted by this crosstalk play a major role in cancer development, progression, and therapeutic management. An increased infiltration of Tumor-associated macrophages (TAMs) was observed in most of the human cancers, including lung cancer. In this review, we emphasize the role of cytokines and chemokines in TAM-tumor cell crosstalk in the lung TME. Given the role of cytokines and chemokines in immunomodulation, we propose that TAM-derived cytokines and chemokines govern the cancer-promoting immune responses in the TME and offer a new immunotherapeutic option for lung cancer treatment.
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Metadaten
Author:Poonam Sarode, Martina Barbara Schaefer, Friedrich Grimminger, Werner Seeger, Rajkumar Savai
URN:urn:nbn:de:hebis:30:3-544782
DOI:http://dx.doi.org/10.3389/fonc.2020.00324
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=32219066
Parent Title (English):Frontiers in oncology
Publisher:Frontiers Research Foundation
Place of publication:Lausanne
Document Type:Article
Language:English
Date of Publication (online):2020/03/11
Date of first Publication:2020/03/11
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/04/09
Tag:chemokines; cytokines; lung cancer; tumor microenvironment; tumor-associated macrophages
Volume:10
Issue:324
Pagenumber:11
Note:
Copyright © 2020 Sarode, Schaefer, Grimminger, Seeger and Savai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
HeBIS PPN:464702895
Institutes:Medizin
Dewey Decimal Classification:610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0

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